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  • Home
  • Research
  • Publications
  • Team
  • News
  • Open Positions
  • Contact
  • More
    • Home
    • Research
    • Publications
    • Team
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KIM LAB at Case Western Reserve University

PUBLICATIONS

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Publications from postdoctoral fellowship

Poly(ADP-ribosyl)ation enhances nucleosome dynamics and organizes DNA damage repair components within biomolecular condensates. Molecular Cell 2024, 84, 1–18. 

Nosella, M.L.*, Kim, T.H.*, Huang, S.K., Harkness R.W.,Goncalves M., Pan A., Tereshchenko M., Vahidi S., Rubinstein J.L., Lee H.O., Forman-Kay J.D., Kay L.E. (*Both authors contributed equally).

Correlating histone acetylation with nucleosome core particle dynamics and function. Proceedings of the National Academy of Sciences 2023, 120 (15) e2301063120. 

Kim, T.H.*, †, Nosella, M.L.*, Bolik-Coulon, N., Harkness, R.W., Huang, S.K., and Kay, L.E. † (*Both authors contributed equally, † Co-corresponding authors).

Interaction hot spots for phase separation revealed by NMR studies of a CAPRIN1 condensed phase. Proceedings of the National Academy of Sciences 2021, 118 (23) e2104897118. 

Kim, T. H., Payliss, B. J., Nosella, M. L., Lee, I. T. W., Toyama, Y., Forman-Kay, J. D., Kay, L. E.

Confronting the Invisible: Assignment of Protein 1HN Chemical Shifts in Cases of Extreme Broadening. J. Phys. Chem. Lett. 2020, 11, 9, 3384-3389.

Wong L.E., Kim T. H., Rennella E, Vallurupalli P, and Kay L.E. 

NMR experiments for studies of dilute and condensed protein phases: Application to the phase-separating protein CAPRIN1. J. Am. Chem. Soc. 2020, 142, 5, 2471–2489 

Wong, L. E.*, Kim T. H.*, Muhandiram, D. R., Forman-Kay, J. D., Kay, L. E. (*Both authors contributed equally).

Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation. Science 2019; 365 (6455), 825-829

Kim, T. H.*, Tsang B.*, Vernon R. M., Sonenberg N., Kay L.E., Forman-Kay J. D. (*Both authors contributed equally).

Pi-Pi contacts are an overlooked protein feature relevant to phase separation. eLife 2018; 7, e31486.

Vernon R. M., Chong P. A., Tsang B., Kim T. H., Bah A., Farber P., Lin H., Forman-Kay J. D.

Synergy of cAMP and calcium signaling pathways in CFTR regulation. Proceedings of the National Academy of Sciences 2017, 114 (11), E2086-E2096.

Bozoky B., Ahmadi S., Milman T., Kim T. H., Du K., Di Paola M., Pasyk S., Pekhletski R., Keller J. P., Bear C. E., Forman-Kay J. D.

Publications from PhD projects

Substrate-based Allosteric Regulation of a Homodimeric Enzyme. J. Am. Chem. Soc. 2019; 141 (29), 11540-11556

Mehrabi P.*, Di Pietrantonio C.*, Kim T. H.*, Sljoka A., Taverner K., Ing C., Kruglyak N., Pomès R., Pai E. F., Prosser R. S. (*Contributed equally to this work).

The role of dimer asymmetry and protomer dynamics in enzyme catalysis. Science 2017, 355 (6322), eaag2355

Kim, T. H.*, Mehrabi P.*, Ren Z, Sljoka, A., Ing C., Bezginov. A., Ye L., Pomès, R, Prosser R. S., Pai E. F. (*Both authors contributed equally).

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature 2016, 535 (7612), 448.

Staus, D. P., Strachan, R. T., Manglik, A., Pani, B., Kahsai, A. W., Kim, T. H., Wingler, L. M., Ahn, S., Chatterjee, A., Masoudi, A., Kruse, A. C., Pardon, E., Steyaert, J., Weis, W. I., Prosser, R. S., Kobilka, B. K., Costa, T., Lefkowitz, R. J.

Structural insights into the dynamic process of β2-adrenergic receptor signaling. Cell 2015, 161, 1101

Manglik, A.*, Kim, T. H.*, Masureel, M., Altenbach, C., Yang, Z., Hilger, D., Lerch, M. T., Kobilka, T. S., Thian, F. S., Hubbell, W. L., Prosser, R. S., Kobilka, B. K. (*Both authors contributed equally).

The role of ligands on the equilibria between functional states of a G protein-coupled receptor. J. Am. Chem. Soc. 2013, 135, 9465–9474.

Kim, T. H., Chung, K. Y., Manglik, A., Hansen, A. L., Dror, R. O., Mildorf, T. J., Shaw, D. E., Kobilka, B. K., Prosser, R. S. 

Role of detergents inconformational exchange of a G protein-coupled receptor. J. Biol. Chem. 2012, 287, 36305–36311

Chung, K. Y.*, Kim, T. H.*, Manglik, A., Alvares, R., Kobilka, B. K., Prosser, R. S. (*Both authors contributed equally).

Kim Lab at Case Western Reserve University

txk560@case.edu

©2022 by Kim Lab at Case Western Reserve University

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